Aripiprazole-d8

Aripiprazole-d8 is intended for use as an internal standard for the quantification of aripiprazole (Cay-19989) by GC- or LC-MS. Aripiprazole is an atypical antipsychotic. It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg. Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette's disorder.Formal Name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy-1,1,2,2,3,3,4,4-d8]-3,4-dihydro-2(1H)-quinolinone. CAS Number: 1089115-04-7. Molecular Formula: C23H19Cl2D8N3O2. Formula Weight: 456.4. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.12 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. SMILES: ClC1=CC=CC(N2CCN(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OC3=CC=C(CCC(N4)=O)C4=C3)CC2)=C1Cl. InChi Code: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)/i1D2,2D2,10D2,15D2. InChi Key: CEUORZQYGODEFX-BQLKVSHCSA-N.