Amorolfine (hydrochloride)

Amorolfine is an antifungal. It is active against isolates of T. rubrum, T. mentagrophytes, and C. albicans (MIC90s = 4-15, 4-60, and =30-500 ng/ml, respectively). It inhibits the growth of T. mentagrophytes and T. rubrum by 33.7 and 38.5%, respectively, in an in vitro bovine hoof model of onychomycosis. Amorolfine also decreases the fungal burden in a rabbit model of onychomycosis when used as a 5% nail lacquer. Formulations containing amorolfine have been used in the treatment of fungal infections of the toe- or fingernails.Formal Name: (2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, monohydrochloride. CAS Number: 78613-38-4. Synonyms: Ro 14-4767/002. Molecular Formula: C21H35NO . HCl. Formula Weight: 354.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 213, 219, 279, 318 nm. SMILES: CC(CC1=CC=C(C(C)(C)CC)C=C1)CN2C[C@@H](C)O[C@@H](C)C2.Cl. InChi Code: InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22,/h8-11,16-18H,7,12-15H2,1-6H3,1H/t16?,17-,18+,. InChi Key: XZKWIPVTHGWDCF-KUZYQSSXSA-N.