alpha-hydroxy Tamoxifen

alpha-hydroxy Tamoxifen is a reactive metabolite of the estrogen receptor (ER) modulator tamoxifen (Cay-13258) that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.Formal Name: (betaE)-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-alpha-methyl-benzeneethanol. CAS Number: 97151-02-5. Molecular Formula: C26H29NO2. Formula Weight: 387.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 2 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 237 nm. SMILES: CC(O)/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3. InChi Code: InChI=1S/C26H29NO2/c1-20(28)25(21-10-6-4-7-11-21)26(22-12-8-5-9-13-22)23-14-16-24(17-15-23)29-19-18-27(2)3/h4-17,20,28H,18-19H2,1-3H3/b26-25-. InChi Key: BPHFBQJMFWCHGH-QPLCGJKRSA-N.