AHU377 (calcium salt)

AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used for the treatment of mild to moderate hypertension and chronic heart failure.Formal Name: (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid, 4-ethyl ester, hemicalcium salt. CAS Number: 1369773-39-6. Synonyms: Sacubitril. Molecular Formula: C24H28NO5 . 1/2Ca. Formula Weight: 430.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 254 nm. SMILES: C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.[Ca+2]. InChi Code: InChI=1S/2C24H29NO5.Ca/c2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19,/h2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28),/q,,+2/p-2/t2*17-,21+,/m11./s1. InChi Key: DDLCKLBRBPYKQS-OXXXZDCLSA-L.