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Sacubitril hemicalcium salt
Artikelnummer: TGM-T4200-10mg
Description: Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin...
| Schlagworte: | AHU377 calcium salt, AHU-377 (hemicalcium salt) |
| Anwendung: | Neprilysin inhibitor |
| CAS | 1369773-39-6 |
| MW: | 861.06 D |
ab 34,00 €
AHU377 (calcium salt)
Artikelnummer: Cay21473-10
AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in...
| Schlagworte: | Sacubitril, (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid, 4-ethyl... |
| Anwendung: | Neprilysin inhibitor |
| CAS | 1369773-39-6 |
| MW: | 430.5 D |
ab 94,00 €
