AGK2

Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 µM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. It rescues dopamine neurons from alpha-synuclein toxicity in both in vitro and in vivo Parkinson's disease models, mimicking the effect of siRNA-mediated blockade of SIRT2 expression. AGK2 may be a useful tool for studying the roles of SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.Formal Name: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide. CAS Number: 304896-28-4. Molecular Formula: C23H13Cl2N3O2. Formula Weight: 434.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 1 mg/ml. lambdamax: 222, 383 nm. SMILES: O=C(/C(C#N)=C/C1=CC=C(C2=CC(Cl)=CC=C2Cl)O1)NC3=C(C=CC=N4)C4=CC=C3. InChi Code: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+. InChi Key: SVENPFFEMUOOGK-SDNWHVSQSA-N.