Zu "K11412" wurden 109 Artikel gefunden!
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NEU
Anti-Recombinant SIRT2, clone C112437
Artikelnummer: E-AN302817L.100
Protein function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414,...
| Schlagworte: | Anti-SIRT2, Anti-SIR2-like protein 2, Anti-Regulatory protein SIR2 homolog 2, Anti-NAD-dependent protein deacetylase... |
| Anwendung: | WB, IHC, IF, IP, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
NEU
Anti-Recombinant SIRT2, clone C123116
Artikelnummer: E-AN303496L.100
Protein function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414,...
| Schlagworte: | Anti-SIRT2, Anti-SIR2-like protein 2, Anti-Regulatory protein SIR2 homolog 2, Anti-NAD-dependent protein deacetylase... |
| Anwendung: | WB, IHC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
NEU
Recombinant SIRT2 Enzyme, Active, Human
Artikelnummer: BBL-2342
Active, full-length human SIRT2 (AA 1-389) protein expressed and purified from Baculovirus infected insect cells with a C-Terminal His tag. The enzyme has been thoroughly validated with the Transcreener OAADPr Assay Kit. For specific activity, please refer to the Certificate of Analysis for each individual enzyme...
| Schlagworte: | SIRT2, SIR2-like protein 2, Regulatory protein SIR2 homolog 2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent... |
| Anwendung: | HTS, drug discovery, enzyme assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
ab 443,00 €
NEU
Enzolution(R) SIRT2 FP Assay System
Artikelnummer: BBL-3049-10K-FP
The Enzolution(R) SIRT2 Assay System is intended for use with the Transcreener(R) OAADPr SIRT Assay Kits (Parts #3046 and #3047) to measure the enzymatic activity of SIRT2 (NAD-dependent protein deacetylase sirtuin 2). SIRT2 catalyzes transfer of acetyl groups from lysine residues to NAD, yielding the unacetylated...
| Schlagworte: | SIRT2, SIR2-like protein 2, Regulatory protein SIR2 homolog 2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent... |
| Anwendung: | HTS, drug discovery, enzyme assays |
ab 683,00 €
NEU
Enzolution(R) SIRT2 TR-FRET Assay System
Artikelnummer: BBL-3049-10K-TR
The Enzolution(R) SIRT2 Assay System is intended for use with the Transcreener(R) OAADPr SIRT Assay Kits (Parts #3046 and #3047) to measure the enzymatic activity of SIRT2 (NAD-dependent protein deacetylase sirtuin 2). SIRT2 catalyzes transfer of acetyl groups from lysine residues to NAD, yielding the unacetylated...
| Schlagworte: | SIRT2, SIR2-like protein 2, Regulatory protein SIR2 homolog 2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent... |
| Anwendung: | HTS, drug discovery, enzyme assays |
ab 740,00 €
SirReal1-O-Propargyl
Artikelnummer: Cay45592-1
SirReal1-O-propargyl is an inhibitor of sirtuin 2 (SIRT2, IC50 = 2.4 µM) and a proteolysis-targeting chimera (PROTAC) building block. It is selective for SIRT2 over SIRT1 (IC50 = >100 µM). When conjugated with azido-thalidomide (Cay26146), SirReal1-O-propargyl has been used in the synthesis of a PROTAC that drives...
| Schlagworte: | 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]-acetamide |
| Anwendung: | SIRT2 inhibitor |
| CAS | 1862237-99-7 |
| MW: | 424.54 D |
ab 83,00 €
Anti-Recombinant SIRT2, clone A435
Artikelnummer: E-AN301727L.100
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) is a NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. SIRT2 participates in the modulation of multiple and diverse biological processes such as cell...
| Schlagworte: | Anti-SIRT2, Anti-SIR2-like protein 2, Anti-Regulatory protein SIR2 homolog 2, Anti-NAD-dependent protein deacetylase... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 303,00 €
Tenovin-6 (hydrochloride)
Artikelnummer: Cay13086-1
The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces...
| Schlagworte: | N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide |
| Anwendung: | SIRT inhibitor |
| CAS | 1011301-29-3 |
| MW: | 491.1 D |
ab 74,00 €
Sirtinol
Artikelnummer: Cay10523-5
Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 µM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 µM, respectively. It does not alter HDAC1 activity. Sirtinol inhibits the growth of cancer cells and...
| Schlagworte: | Sir Two Inhibitor Naphthol, 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide |
| Anwendung: | Sirtuin inhibitor |
| CAS | 410536-97-9 |
| MW: | 394.5 D |
ab 105,00 €
Tenovin-1
Artikelnummer: Cay13085-10
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt's lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by...
| Schlagworte: | N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide |
| Anwendung: | SIRT inhibitor |
| CAS | 380315-80-0 |
| MW: | 369.5 D |
ab 53,00 €
Sirtuin 2, active human recombinant protein
Artikelnummer: BPS-50013
Active human Sirtuin 2, GenBank Accession No. NM_030593, amino acids 13-319 with C-terminal His tag, MW= 35.5 kDa, expressed in E. coli expression system.
| Schlagworte: | SIRT2, SIR2L, SIR2-like protein 2, Regulatory protein SIR2 homolog 2, NAD-dependent protein deacetylase sirtuin-2,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 35.5 kD |
693,00 €
Salermide
Artikelnummer: Cay13178-10
The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells,...
| Schlagworte: | N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide |
| Anwendung: | SIRT inhibitor |
| CAS | 1105698-15-4 |
| MW: | 394.5 D |
ab 78,00 €