Zu "K11412" wurden 92 Artikel gefunden!
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Anti-SIRT2
Artikelnummer: ABS-KC-6092.100
Protein function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414,...
| Schlagworte: | Anti-NAD-dependent protein deacetylase sirtuin-2, Anti-NAD-dependent protein defatty-acylase sirtuin-2, Anti-Regulatory... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 232,00 €
Anti-SIRT2 Recombinant
Artikelnummer: ABS-KC-3045.100
Protein function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414,...
| Schlagworte: | Recombinant SIRT2 Antibody |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 232,00 €
Tenovin-6
Artikelnummer: TGM-T1818-100mg
Description: Tenovin-6 is a p53 transcriptional activity agonist. Target: Autophagy, Dehydrogenase, Sirtuin. Smiles: CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1. References: Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.
| Schlagworte: | Tenovin 6 |
| Anwendung: | SIRT inhibitor |
| CAS | 1011557-82-6 |
| MW: | 454.63 D |
ab 37,00 €
Tenovin-3
Artikelnummer: TGM-T1873-100mg
Description: Tenovin-3 acts as a p53 activator. Target: Sirtuin. Smiles: CC(C)(C)c1ccc(cc1)C(=O)NC(=S)Nc1ccc(N)cc1. References: Ma L, et al. Cell Death Dis. 2014 Oct 23,5:e1483.
| Schlagworte: | Tenovin3 |
| Anwendung: | SIRT2 Inhibitor |
| CAS | 1011301-27-1 |
| MW: | 327.44 D |
ab 55,00 €
Tenovin-1
Artikelnummer: TGM-T1919-100mg
Description: Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. Target: Dehydrogenase, Autophagy, Sirtuin, p53, Mdm2. Smiles: CC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1. References: Lain S, et al. Cancer...
| Schlagworte: | Tenovin 1 |
| Anwendung: | SIRT inhibitor |
| CAS | 380315-80-0 |
| MW: | 369.48 D |
ab 37,00 €
AGK2
Artikelnummer: TGM-T6371-100mg
Description: AGK2(IC50=3.5 µM) is an effective, and specific SIRT2 inhibitor. Target: Apoptosis, Sirtuin. Smiles: Clc1ccc(Cl)c(c1)-c1ccc(C=C(C#N)C(=O)Nc2cccc3ncccc23)o1. References: Outeiro TF, et al. Science.2007, 317(5837), 516-519.
| Anwendung: | SIRT2 inhibitor |
| CAS | 304896-28-4 |
| MW: | 434.27 D |
ab 31,00 €
JFD00244
Artikelnummer: TGM-T15610-10mg
Description: JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect. Target: Others. Smiles: Oc1ccc(CCNc2ccc(NCCc3ccc(O)cc3)c3C(=O)c4ccccc4C(=O)c23)cc1. References: Ciarlo C, A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development....
| Anwendung: | SIRT2 inhibitor |
| CAS | 96969-83-4 |
| MW: | 478.54 D |
ab 77,00 €
Thiomyristoyl
Artikelnummer: TGM-T3447-100mg
Description: Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 µM) but no effect on SIRT3 even at 200 µM. Target: Sirtuin. Smiles: CCCCCCCCCC CCCC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1. References: Jing H, et al. Cancer Cell. 2016, 29(3):297-310.
| Anwendung: | Selective SIRT2 inhibitor |
| CAS | 1429749-41-6 |
| MW: | 581.85 D |
ab 52,00 €
Salermide
Artikelnummer: TGM-T3953-100mg
Description: Salermide, an inhibitor of Sirt1 and Sirt2, induces cancer-specific apoptotic cell death. Target: Sirtuin, Apoptosis. Smiles: CC(C(=O)Nc1cccc(c1)\N=C\c1c(O)ccc2ccccc12)c1ccccc1. References: Lara E, et al. Oncogene. 2009, 28(6):781-91.
| Anwendung: | SIRT inhibitor |
| CAS | 1105698-15-4 |
| MW: | 394.47 D |
ab 42,00 €
AK-7
Artikelnummer: TGM-T5490-100mg
Description: AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 µM. Target: Sirtuin. Smiles: Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N2CCCCCC2)c1. References: Taylor DM, et al. A brain-permeable small molecule reduces neuronal...
| Anwendung: | SIRT2 Inhibitor |
| CAS | 420831-40-9 |
| MW: | 437.35 D |
ab 31,00 €
SirReal2
Artikelnummer: TGM-T6984-100mg
Description: SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Target: Sirtuin. Smiles: Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc4ccccc34)s2)n1. References: Rumpf T, et al. Nat Commun. 2015, 6, 6263.
| Anwendung: | SIRT2 inhibitor |
| CAS | 709002-46-0 |
| MW: | 420.55 D |
ab 34,00 €
Tenovin-6 Hydrochloride
Artikelnummer: TGM-T8480-100mg
Description: Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 µM, 10 µM, and 67 µM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . Target: Autophagy, Sirtuin, p53, Dehydrogenase, HDAC. Smiles: Cl.CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1....
| Anwendung: | SIRT inhibitor |
| CAS | 1011301-29-3 |
| MW: | 491.09 D |
ab 34,00 €