ACY-738

ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 1.7 nM). It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of alpha-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine (Cay-11764). It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.Formal Name: N-hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide. CAS Number: 1375465-91-0. Molecular Formula: C14H14N4O2. Formula Weight: 270.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 267 nm. SMILES: O=C(NO)C1=CN=C(NC2(CC2)C3=CC=CC=C3)N=C1. InChi Code: InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17). InChi Key: LIIWIMDSZVNYHY-UHFFFAOYSA-N.