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ACY-738
Artikelnummer: TGM-T3509-100mg
Description: ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold. Target: HDAC. Smiles: N(C1(CC1)C2=CC=CC=C2)C=3N=CC(C(NO)=O)=CN3. References: Jochems J, et al Antidepressant-like properties of novel HDAC6-selective...
| Schlagworte: | ACY 738 |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1375465-91-0 |
| MW: | 270.29 D |
ab 42,00 €
ACY-738
Artikelnummer: Cay28282-1
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 1.7 nM). It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of alpha-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility...
| Schlagworte: | N-hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1375465-91-0 |
| MW: | 270.3 D |
ab 85,00 €
