ACY-1083

An HDAC6 inhibitor (IC50 = 3 nM), increases the levels of acetylated alpha-tubulin in SK-N-BE(2) cells in a concentration-dependent manner, prevents cisplatin-induced decreases in mitochondrial OCR and mitochondrial motility in tibial nerves isolated from mice at 10 mg/kg per day, inhibits cisplatin-induced decreases in the mechanical pain threshold in the von Frey test in mice, prevents doxorubicin-induced decreases in learning and memory in the puzzle box test in mice