ACHP

Description: ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-alpha and IKK-beta. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression through inhibition of NF-kappaB activation, inhibits TNF-alpha-induced NF-kappaB (p65) recruitment to the HIV-1 LTR, and inhibits TNF-alpha-induced NF-kappaB (p65) recruitment to the HIV-1 LTR. ACHKP has anti-HIV-1 activity and inhibits TNF-alpha-induced recruitment of NF-kappaB (p65) to the HIV-1 LTR. Target: IkappaB/IKK. Smiles: N#CC1=C(N=C(C=C1C2CCNCC2)C=3C(O)=CC=CC3OCC4CC4)N. References: Pandur, E., et al. Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages. BMC Complement Med Ther 21, 287 (2021).