A-966492

A-966492 is a dual inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (Kis = 1 and 1.5 nM, respectively). It reduces tumor growth by 46 and 92% in an MX-1 mouse xenograft model when administered at doses of 100 and 200 mg/kg per day, respectively. A-966492 also reduces tumor growth in a B16/F10 murine melanoma model when administered in combination with temozolomide (Cay-14163).Formal Name: 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide. CAS Number: 934162-61-5. Molecular Formula: C18H17FN4O. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: NC(C1=C(NC(C2=CC=C([C@H]3NCCC3)C=C2F)=N4)C4=CC=C1)=O. InChi Code: InChI=1S/C18H17FN4O/c19-13-9-10(14-5-2-8-21-14)6-7-11(13)18-22-15-4-1-3-12(17(20)24)16(15)23-18/h1,3-4,6-7,9,14,21H,2,5,8H2,(H2,20,24)(H,22,23)/t14-/m0/s1. InChi Key: AHIVQGOUBLVTCB-AWEZNQCLSA-N.