9-ING-41

9-ING-41 is an inhibitor of glycogen synthase kinase 3beta (GSK3beta, IC50 = 0.71 µM). It inhibits the growth of MiaPaCa-2, BxPC-3, and HuP-T3 pancreatic cancer cells (IC50s = 5, 1, and 0.6 µM, respectively). 9-ING-41 (5 µM) inhibits GSK3beta phosphorylation and induces apoptosis in BxPC-3 and HuP-T3 cells. In vivo, 9-ING-41 (40 mg/kg) reduces tumor growth in an SKOV3 mouse xenograft model. It also reduces pleural thickening and improves lung function in a mouse model of S. pneumoniae-induced empyema.Formal Name: 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione. CAS Number: 1034895-42-5. Synonyms: Elraglusib. Molecular Formula: C22H13FN2O5. Formula Weight: 404.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. SMILES: O=C1NC(C(C2=CN(C)C3=C2C=C4OCOC4=C3)=C1C5=COC6=C5C=C(F)C=C6)=O. InChi Code: InChI=1S/C22H13FN2O5/c1-25-7-13(11-5-17-18(6-15(11)25)30-9-29-17)19-20(22(27)24-21(19)26)14-8-28-16-3-2-10(23)4-12(14)16/h2-8H,9H2,1H3,(H,24,26,27). InChi Key: FARXPFGGGGLENU-UHFFFAOYSA-N.