7,8-Dihydroxyflavone

7,8-Dihydroxyflavone (7,8-DHF) is a flavone that has been found in G. aesculifolia and has diverse biological activities. It binds to tropomyosin-related kinase B (TrkB, Kd = 320 nM) and induces TrkB autophosphorylation in primary mouse hippocampal neurons. In vivo, 7,8-DHF (5 mg/kg) reduces neuronal apoptosis and reduces infarct volume in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO). It reduces striatal nigral neuronal apoptosis in a mouse model of MPTP-induced Parkinson's disease. 7,8-DHF (5 mg/kg) increases survival, neocortical volume, and whole brain volume in an N171-82Q mouse model of Huntington's disease. It increases bone mineral density and reduces bone loss in a rat model of ovariectomy-induced osteoporosis when administered at a dose of 10 mg/kg. 7,8-DHF (5 mg/kg per day, i.p.) reduces blood glucose levels, pancreatic vascular congestion, and inflammatory cell infiltration, as well as hepatic vascular congestion and DNA damage-inducible transcript 3 (DDIT3) and glucose-regulated protein 78 (GRP78) levels, markers of endoplasmic reticulum (ER) stress, in a mouse model of cafeteria diet-induced metabolic syndrome.Formal Name: 7,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one. CAS Number: 38183-03-8. Synonyms: 7,8-DHF. Molecular Formula: C15H10O4. Formula Weight: 254.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 210, 270 nm. SMILES: O=C1C2=C(C(O)=C(O)C=C2)OC(C3=CC=CC=C3)=C1. InChi Code: InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H. InChi Key: COCYGNDCWFKTMF-UHFFFAOYSA-N. Origin: Synthetic.