(5Z,2E)-CU-3

(5Z,2E)-CU-3 is an inhibitor of diacylglycerol kinase alpha (DGK-alpha, IC50 = 0.6 µM for the porcine enzyme). It is selective for DGK-alpha over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM). (5Z,2E)-CU-3 (5 µM) induces apoptosis in HeLa cervical and HepG2 liver cancer cells and enhances increases in IL2 mRNA expression in Jurkat T cells induced with concanavalin A (Cay-14951).Formal Name: N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide. CAS Number: 1815598-71-0. Molecular Formula: C16H12N2O4S3. Formula Weight: 392.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml. lambdamax: 419 nm. SMILES: O=S(NN1C(/C(SC1=S)=C/C=C/C2=CC=CO2)=O)(C3=CC=CC=C3)=O. InChi Code: InChI=1S/C16H12N2O4S3/c19-15-14(10-4-6-12-7-5-11-22-12)24-16(23)18(15)17-25(20,21)13-8-2-1-3-9-13/h1-11,17H/b6-4+,14-10-. InChi Key: YIUMXULORVBWLL-SPGDJUBISA-N.