5-LOX-IN-2

Description: 5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 µM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research. Target: Apoptosis, Lipoxygenase. Smiles: C(=C/C(OCCC1=CC=CC=C1)=O)\C2=C(O)C=CC(O)=C2. References: Selka A, et.al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. Eur J Med Chem. 2019 Oct 1,179:347-357.