3-Aminopropylphosphonic Acid

3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 µM in a radioligand binding assay). It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.Formal Name: P-(3-aminopropyl)-phosphonic acid. CAS Number: 13138-33-5. Synonyms: beta-Aminopropylphosphonic Acid, 3-APPA, NSC 133832. Molecular Formula: C3H10NO3P. Formula Weight: 139.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: NCCCP(O)(O)=O. InChi Code: InChI=1S/C3H10NO3P/c4-2-1-3-8(5,6)7/h1-4H2,(H2,5,6,7). InChi Key: GSZQTIFGANBTNF-UHFFFAOYSA-N.