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Zu "K04615" wurden 61 Artikel gefunden!
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Artikelnummer: Cay21912-5
CGP 55845 is a GABAB receptor antagonist (Ki = 4.5 nM). It increases electrical stimulation-induced GABA release in the absence and presence of the GABAB receptor agonist (-)-baclofen, as well as glutamate release in the presence of (-)-baclofen, in rat cerebral cortex slices (EC50s = 8.3, 25, and 14 nM,...
Schlagworte: | CGP 55845A, P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-P-(phenylmethyl)-phosphinic acid,... |
Anwendung: | GABAB receptor antagonist |
CAS | 149184-22-5 |
MW: | 438.7 D |
ab 145,00 €
Artikelnummer: ELK-ELK0929.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GABBR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GABBR1. Next,...
Schlagworte: | Gb1, Gabbr1, GABABR1, GABA-BR1, GABA-B-R1, GABA-B receptor 1, Gamma-aminobutyric acid type B receptor subunit 1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 303,00 €
Artikelnummer: ELK-EA288.100
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316,...
Schlagworte: | Anti-Gb2, Anti-HG20, Anti-GPR51, Anti-GABBR2, Anti-GABABR2, Anti-GABA-BR2, Anti-GABA-B-R2, Anti-GABA-B receptor 2,... |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
283,00 €
Artikelnummer: Cay18600-1
(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM). It induces norepinephrine release from isolated rat atria (IC50 = 4.5 µM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice. It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats. (±)-Baclofen also reduces...
Schlagworte: | beta-(aminomethyl)-4-chloro-benzenepropanoic acid |
Anwendung: | GABA-B receptor agonist |
CAS | 1134-47-0 |
MW: | 213.7 D |
ab 60,00 €
Artikelnummer: Cay27326-10
(±)-Baclofen (Cay-27326) is an analytical reference standard categorized as a gabapentinoid and a nootropic. (±)-Baclofen also has analgesic, skeletal muscle relaxant, and sedative properties. Formulations containing (±)-baclofen have been used in the treatment of spasticity in patients with multiple sclerosis or...
Schlagworte: | beta-(aminomethyl)-4-chloro-benzenepropanoic acid |
Anwendung: | Analytical reference standard, Centrally acting muscle relaxant, Gabapentinoid, Nootropic |
CAS | 1134-47-0 |
MW: | 213.7 D |
ab 66,00 €
Artikelnummer: Cay20121-10
CGP 54626 is a selective antagonist of the GABAB receptor with an IC50 value of 4 nM. It can be used to investigate the role of GABAB receptors in neurological signaling.Formal Name: P-(cyclohexylmethyl)-P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-phosphinic acid, monohydrochloride. CAS...
Schlagworte: | CGP 54626A, P-(cyclohexylmethyl)-P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-phosphinic acid,... |
Anwendung: | GABA(B) receptor antagonist |
CAS | 149184-21-4 |
MW: | 444.8 D |
ab 43,00 €
Artikelnummer: Cay17355-5
Saclofen is a sulfonic analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM). This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in...
Schlagworte: | b-(aminomethyl)-4-chloro-benzeneethanesulfonic acid |
Anwendung: | Competitive GABAB receptor antagonist |
CAS | 125464-42-8 |
MW: | 249.7 D |
ab 115,00 €
Artikelnummer: Cay31595-25
(+)-Baclofen is a GABAB receptor agonist. In vivo, (+)-baclofen (1 and 3 mg/kg) increases latency to paw or tail withdrawal in the hot-plate test in mice. (+)-Baclofen (3 mg/kg) also reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats.Formal Name:...
Schlagworte: | (R)-Baclofen, betaR-(aminomethyl)-4-chloro-benzenepropanoic acid, monohydrochloride |
Anwendung: | GABA(B) receptor agonist |
CAS | 63701-55-3 |
MW: | 250.1 D |
ab 48,00 €
Artikelnummer: ARG22242.50
Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine...
Schlagworte: | Anti-Gb2, Anti-Gpr51, Anti-Gabbr2, Anti-GABABR2, Anti-GABA-BR2, Anti-GABA-B-R2, Anti-GABA-B receptor 2, Anti-G-protein... |
Anwendung: | WB, IHC, ICC, IF |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
520,00 €
Artikelnummer: ARG22243.50
Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine...
Schlagworte: | Anti-Gb1, Anti-Gabbr1, Anti-GABABR1, Anti-GABA-BR1, Anti-GABA-B-R1, Anti-GABA-B receptor 1, Anti-Gamma-aminobutyric acid... |
Anwendung: | WB, ICC, IF |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
520,00 €
Artikelnummer: 612-401-D53
Anti-GABA(A) Receptor 2 pS783 Antibody is directed against rat phosphorylated GABA(A) Receptor 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAB R2 band is completely blocked by ?-phosphatase treatment. Reactivity is expected from the...
Schlagworte: | Anti-phospho-Gb2, Anti-phospho-Gpr51, Anti-phospho-Gabbr2, Anti-phospho-GABABR2, Anti-phospho-GABA-BR2,... |
Anwendung: | IFM, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | rat |
684,00 €
Artikelnummer: 612-401-D54
Anti-GABA(A) Receptor 1 pS923 Antibody is directed against rat phosphorylated GABA(A) Receptor 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAB R1 band is completely blocked by ?-phosphatase treatment. Reactivity is expected from the...
Schlagworte: | Anti-phospho-Gb1, Anti-phospho-Gabbr1, Anti-phospho-GABABR1, Anti-phospho-GABA-BR1, Anti-phospho-GABA-B-R1,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | rat |
684,00 €