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Reporter-Assays

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Prostaglandin F Receptor Reporter Assay Kit
Prostaglandin F Receptor Reporter Assay Kit

Artikelnummer: Cay601800-1

Prostaglandin F2alpha (PGF2alpha) is a biologically important prostanoid that exerts its actions through binding to the PGF2alpha receptor (FP). PGF2alpha is synthesized in many tissues, including the eye and organs of the female reproductive system. Activation of ocular FP receptors via agonists such as bimatoprost...
Schlagworte: PTGFR, PGF receptor, PGF2-alpha receptor, Prostanoid FP receptor, Prostaglandin F2-alpha receptor
Anwendung: Luminescent reporter assay
500,00 €
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Secreted Alkaline Phosphatase Reporter Gene Assay Kit (Luminescence)
Secreted Alkaline Phosphatase Reporter Gene Assay Kit...

Artikelnummer: Cay600260-300

Secreted alkaline phosphatase (SEAP) is commonly used as a reporter of gene expression. Compared to other conventional intracellular reporters such as chloramphenicol acetyltransferase (CAT) and firefly luciferase, SEAP has the advantage of being secreted from transfected cells into the culture medium. Cayman's...
Schlagworte: SEAP Reporter Gene
Anwendung: Chemiluminescence
287,00 €
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One-Step Luciferase Assay System
One-Step Luciferase Assay System

Artikelnummer: BPS-60690-1

The One-Step Luciferase Assay System is designed to be used for high-throughput, sensitive quantitation of firefly luciferase activity in mammalian cell culture. The reagent consists of two components, a Luciferase Reagent Buffer (Component A) and Luciferase Reagent Substrate (Component B). Component A and Component...
Anwendung: Firefly luciferase assays, HTS
ab 158,00 €
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AR (human) Reporter Assay Kit
AR (human) Reporter Assay Kit

Artikelnummer: IB-IB03001-32

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of full-length, unmodified human androgen receptor (NR3C4), a ligand-dependent transcription factor commonly referred to as AR. INDIGO's reporter cells include the luciferase...
Schlagworte: AR, DHTR, Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.068,00 €
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Notch Reporter Assay Kit (cAMP/PKA pathway)
Notch Reporter Assay Kit (cAMP/PKA pathway)

Artikelnummer: BPS-60509

Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready Notch1 NICD expression vector and CSL (CBF1/RBP-Jkappa) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a...
Anwendung: Notch activity assays
748,00 €
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FXR (mouse) Reporter Assay Kit
FXR (mouse) Reporter Assay Kit

Artikelnummer: IB-M00601-32

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human farnesoid X receptor (NR1H4), a ligand-dependent transcription factor commonly referred to as FXR. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: Bar, Nr1h4, Bile acid receptor, Farnesol receptor HRR-1, RXR-interacting protein 14, Farnesoid X-activated receptor,...
Anwendung: Functional activity screening
Reaktivität: Mouse
ab 1.068,00 €
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PXR (human) Reporter Assay Kit
PXR (human) Reporter Assay Kit

Artikelnummer: IB-IB07001

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
Schlagworte: SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.068,00 €
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RORa (Human) Reporter Assay System
RORa (Human) Reporter Assay System

Artikelnummer: IB-IB04011-32

Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid,...
Schlagworte: RORA, NR1F1, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, RAR-related orphan receptor A, Retinoid-related...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.068,00 €
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CYP2B6 Induction Reporter Assay Kit
CYP2B6 Induction Reporter Assay Kit

Artikelnummer: Cay600680-100

Early screening of a drug candidate's potential to induce or inhibit CYP2B6 is a critical step in the drug development process. Cayman's CYP2B6 Induction Reporter Assay Kit is a novel method to evaluate human Constitutive Androstane Receptor 3 (hCAR3)-mediated CYP2B6 induction for the discovery of hepatic CYP...
Schlagworte: CYP2B6 Induction STEP Reporter Assay Kit (Luminescence)
Anwendung: Reverse transfection reporter assay
500,00 €
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TGR5 (GP-BAR1) Reporter Assay Kit
TGR5 (GP-BAR1) Reporter Assay Kit

Artikelnummer: Cay601440-1

Bile acids are a diverse class of amphipathic molecules originally formed in liver and modified by microorganisms in the intestine. In addition to their conventional role in dietary lipid absorption, bile acids have been recognized as signaling molecules that regulate the synthesis and metabolism of bile acids,...
Schlagworte: BG37, TGR5, M-BAR, hBG37, GPBAR1, hGPCR19, G-protein coupled receptor GPCR19, Membrane-type receptor for bile acids,...
Anwendung: Cell based assays, HTS, Reverse transfection reporter assay
500,00 €
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MR (human) Reporter Assay Kit
MR (human) Reporter Assay Kit

Artikelnummer: IB-IB00502

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human mineralocorticoid receptor (NR3C2), a ligand-dependent transcription factor commonly referred to as MR. INDIGO's reporter cells include the luciferase...
Schlagworte: MR, MCR, NR3C2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2
Anwendung: Functional activity screening
Reaktivität: Human
2.837,00 €
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PR (human) Reporter Assay Kit
PR (human) Reporter Assay Kit

Artikelnummer: IB-IB05002

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the full-length human progesterone receptor (NR3C3), a ligand-dependent transcription factor commonly referred to as PR. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: PR, PGR, NR3C3, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3
Anwendung: Functional activity screening
Reaktivität: Human
2.837,00 €
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