Human TrkA ELISA Kit

Human TrkA ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0508 1 kit - -

1 - 9 Werktage

737,00 €
 
Natural and recombinant human TrkA. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Human TrkA ELISA Kit"
Natural and recombinant human TrkA. There is no detectable cross-reactivity with other relevant proteins. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. [The UniProt Consortium]
Schlagworte: MTC, NTRK1, Trk-A, gp140trk, p140-TrkA, EC=2.7.10.1, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A, TRK1-transforming tyrosine kinase protein, High affinity nerve growth factor receptor
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0508

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: NSO, Immunogen sequence: A33-E407
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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