Anti-phospho-ZAP70 (Tyr493)

Anti-phospho-ZAP70 (Tyr493)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-008A-T 10 µl (10 µg) -

3 - 9 Werktage

125,00 €
A302-008A 100 µl (100 µg) -

3 - 9 Werktage

459,00 €
 
Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive... mehr
Produktinformationen "Anti-phospho-ZAP70 (Tyr493)"
Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). [The UniProt Consortium]
Schlagworte: Anti-phospho-SRK, Anti-phospho-ZAP70, EC=2.7.10.2, Anti-phospho-Syk-related tyrosine kinase, Anti-phospho-Tyrosine-protein kinase ZAP-70, Anti-phospho-70 kDa zeta-chain associated protein
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-008A-T

Eigenschaften

Anwendung: IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A302-008A-T maps to a region including tyrosine 493 (when it is phosphorylated) of human zeta-chain (TCR) associated protein kinase 70kDa using the numbering given in entry NP_001070.2 (GeneID 7535).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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