Anti-phospho-Tau (Ser416)

Anti-Tau pS416 antibody is directed against rat Tau. Tau pS416 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. This antibody is directed against rat tau protein phosphorylated at Ser416. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human, mouse and non-human primates. Protein function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. [The UniProt Consortium]