Anti-phospho-RelA (Ser536)

Anti-phospho-RelA (Ser536)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-062A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A302-062A-M 100 µl (10 blots) -

3 - 9 Werktage

303,00 €
A302-062A 100 µl (20 µg) -

3 - 9 Werktage

475,00 €
 
Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell... mehr
Produktinformationen "Anti-phospho-RelA (Ser536)"
Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). [The UniProt Consortium]
Schlagworte: Anti-phospho-RELA, Anti-phospho-NFKB3, Anti-phospho-Transcription factor p65, Anti-phospho-Nuclear factor NF-kappa-B p65 subunit, Anti-phospho-Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-062A-T

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A302-062A-T maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 536 when serine 536 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5970).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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