FluoSite Anti-ITGB6 APC Labeled

This anti-ITGB6 (Integrin beta 6) antibody is a purified monoclonal antibody, which is labeled with Allophycocyanin (APC). This antibody has been tested by flow cytometry for specific binding to human ITGB6 on the surface of Detroit 562 cells (ATCC #CCL-138). FluoSite(TM) is a tag-based method for site-specific conjugation of antibodies with fluorophores, ensuring the labeling site is far from the antigen-binding domain to preserve antibody functionality. This precise, consistent labeling ensures the homogeneity of the labeled antibody preparation, making it ideal for flow cytometry and other high-sensitivity applications. ITGB6 is a protein that forms a heterodimer with the integrin alpha v (alphav) subunit, creating the integrin alphavbeta6 complex. ITGB6 is involved in cell adhesion and migration by interacting with the extracellular matrix (ECM). This interaction is essential for tissue repair and regeneration. ITGB6 transduces signals from the ECM to the cell, influencing cell behavior, including proliferation, differentiation, and survival. ITGB6 plays a role in the activation of transforming growth factor-beta (TGF-beta), a cytokine involved in immune regulation, cell growth, and differentiation. ITGB6 is often overexpressed in various cancers, including epithelial carcinoma. ITGB6 is implicated in the development of fibrosis in organs such as the lungs, liver, and kidneys. Targeting ITGB6 could help in treating fibrotic diseases by modulating the TGF-beta pathway. Overall, ITGB6's role in critical cellular processes and disease mechanisms makes it a promising target for therapeutic interventions in cancer, fibrosis, and potentially other conditions.