Anti-XRCC6

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F49016-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F49016-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. The p70/p80 autoantigen is a nuclear complex... mehr
Produktinformationen "Anti-XRCC6"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. Protein function: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. [The UniProt Consortium]
Schlagworte: Anti-TLAA, Anti-Ku70, Anti-CTCBF, Anti-XRCC6, Anti-CTC75, Anti-G22P1, EC=3.6.4.-, EC=4.2.99.-, Anti-5'-dRP lyase Ku70, Anti-DNA repair protein XRCC6, Anti-Thyroid-lupus autoantigen, Anti-70 kDa subunit of Ku antigen, Anti-Lupus Ku autoantigen protein p70,
Hersteller: NSJ Bioreagents
Hersteller-Nr: F49016

Eigenschaften

Anwendung: IHC, FC, IF, WB, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 228-254 from the human protein was used as the immunogen for this XRCC6 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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-30 %
Rabattaktion
Anti-Ku70 Anti-Ku70
624,00 € 436,80 €
Anti-XRCC6 Anti-XRCC6
ab 326,00 €
-30 %
Rabattaktion
Anti-Ku70 Anti-Ku70
624,00 € 436,80 €
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