Anti-XRCC1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R30722 100 µg - -

3 - 10 Werktage*

549,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. X-ray repair, complementing defective, in... mehr
Produktinformationen "Anti-XRCC1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. X-ray repair, complementing defective, in chinese hamster 1 is a DNA repair protein which complexes with DNA ligase III. The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. The XRCC1 gene is mapped to 19q13.31. The protein interacts with DNA ligase III, polymerase beta and poly(ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of ser518, thr519, and thr523 largely determines aprataxin binding to XRCC1 through its FHA domain. Protein function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. [The UniProt Consortium]
Schlagworte: Anti-XRCC1, Anti-DNA repair protein XRCC1, Anti-X-ray repair cross-complementing protein 1, XRCC1 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: R30722

Eigenschaften

Anwendung: WB, IHC (paraffin), ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: An amino acid sequence from the N-terminus of human XRCC1 (QDSTHCAENLLKADTYRKWR) was used as the immunogen for this XRCC1 antibody (100% mouse homology).
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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