Anti-VAMP 2 (Vesicle Associated Membrane Protein 2, Vesicle-associated Membrane Protein 2, VAMP2, VA

VAMP-2 is a member of the vesicle-associated membrane protein (VAMP):synaptobrevin family, which are 18kD integral membrane proteins originally characterized in synaptic vesicles. The protein forms a stable complex with syntaxin, synaptosomal-associated protein and synaptotagmin which are main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP-2 plays a key role in the fusion of synaptic vesicles. VAMP-2 is also expressed in non-neuronal tissue and participates in regulated exocytosis, such as insulin-regulated translocation of glucose transporter-4 (GLUT4)-containing vesicles in adipocytes and insulin secretion in pancreatic beta-cells. In human, the pathological role of the protein has been identified in familial infantile myasthenia (FIMG). The rat VAMP-2 gene is localized on chromosome 10q24. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Brain, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.