Anti-UVRAG

Anti-UVRAG
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A301-996A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A301-996A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A301-996A 100 µl (20 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Versatile protein that is involved in regulation of different cellular pathways... mehr
Produktinformationen "Anti-UVRAG"
Protein function: Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex, the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome, the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex), the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). [The UniProt Consortium]
Schlagworte: Anti-p63, Anti-UVRAG, Anti-UV radiation resistance-associated gene protein
Hersteller: Bethyl Laboratories
Hersteller-Nr: A301-996A-T

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse, Rat, Bovine, Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Chinese Hamster, Naked Mole Rat, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-996A-T maps to a region between residue 649 and 699 of human UV radiation resistance associated gene using the numbering given in entry NP_003360.2 (GeneID 7405).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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