Anti-UFL1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA030559.25 25 µl -

7 - 10 Werktage*

300,00 €
ATA-HPA030559.100 100 µl -

7 - 10 Werktage*

421,00 €
 
Protein function: E3 protein ligase that mediates ufmylation, the covalent attachment of the... mehr
Produktinformationen "Anti-UFL1"
Protein function: E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:32160526). In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets (PubMed:32160526). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha (PubMed:23152784, PubMed:32160526). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:32050156). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor. Mediates ufmylation of DDRGK1 and CDK5RAP3, the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (PubMed:20531390, PubMed:20018847). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6. Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (PubMed:30886146). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor- mediated transcription (PubMed:25219498). Required for hematopoietic stem cell function and hematopoiesis. Required for cardiac homeostasis. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 87% and to rat: 88%
Schlagworte: Anti-E3 UFM1-protein ligase 1, Anti-Novel LZAP-binding protein, Anti-E3 UFM1-protein transferase 1, Anti-Regulator of C53/LZAP and DDRGK1, Anti-Multiple alpha-helix protein located at ER
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA030559

Eigenschaften

Anwendung: WB, IHC, ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QAALTKHLLK SVCTDITNLI FNFLASDLMM AVDDPAAITS EIRKKILSKL SEETKVALTK LHNSLNEKSI EDFISCLDSA AEACDIMVKR (ATA-APrEST77261)

Datenbank Information

KEGG ID : K22755 | Passende Produkte
UniProt ID : O94874 | Passende Produkte
Gene ID : GeneID 23376 | Passende Produkte
Protein Atlas Nr. : ENSG00000014123

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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