Anti-UBR1

Polyclonal Antibody against Human UBR1, Gene description: ubiquitin protein ligase E3 component n-recognin 1, Validated applications: IHC, Uniprot ID: Q8IWV7, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. [The UniProt Consortium] Mouse gene identity: 95% Rat gene identity: 95%