Anti-Ubiquilin 2, clone 6H9

Anti-Ubiquilin 2, clone 6H9
Aktion:

Gratis WB-Box zu jeder Arigo-Bestellung. 

*1
*1 Angebot gültig bis zum 30.04.2019
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG10728.50 50 µl - -

6 - 14 Werktage

439,00 €
 
Protein function: Plays an important role in the regulation of different protein degradation... mehr
Produktinformationen "Anti-Ubiquilin 2, clone 6H9"
Protein function: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor- arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). [The UniProt Consortium]
Schlagworte: Anti-N4BP4, Anti-Chap1, Anti-PLIC-2, Anti-UBQLN2, Anti-hPLIC-2, Anti-HRIHFB2157, Anti-Ubiquilin-2, Anti-DSK2 homolog, Anti-Ubiquitin-like product Chap1/Dsk2, Anti-Protein linking IAP with cytoskeleton 2
Hersteller-Nr: ARG10728050

Eigenschaften

Anwendung: WB, ICC, IF, IHC (frozen)
Antikörper-Typ: Monoclonal
Klon: 6H9
Wirt: Mouse
Reaktivität: Human, Mouse
Immunogen: Human Ubiquilin 2 expressed in and purified from E. coli
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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