Anti-TTF1 (human), Rabbit Monoclonal (RM373)

Recombinant Antibody. This antibody reacts to human TTF1 ((Thyroid transcription factor 1) (Homeobox protein Nkx-2.1). It may also react to mouse and rat TTF1, as predicted by immunogen homology. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. TTF-1 (Thyroid Transcription Factor-1, NK2 Homeobox 1, NKX2-1), a member of the homeodomain-containing transcription factor family, activates the expression of selected genes in the thyroid, lung, and brain. TTF-1 is known to play key roles in the control of embryonic development and differentiation. The expression of TTF-1 is restricted to alveolar type II cells. It has been found in all types of lung cancer but is reported frequently in adenocarcinoma. TTF-1 has been shown to be a favor prognostic factor for survival in non-small-cell lung cancer (NSCLC).