Anti-TSC2

Anti-TSC2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TSC2 from other sources has not been determined. Protein function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. [The UniProt Consortium]