Anti-TRMT61B

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Enables mRNA (adenine-N1-)-methyltransferase activity, rRNA (adenine) methyltransferase activity, and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation, mitochondrial tRNA methylation, and protein homooligomerization. Located in mitochondrion. Protein function: Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). [The UniProt Consortium]