Anti-Translin

Anti-Translin Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least two isoforms of Translin are known to exist, this antibody will detect both. Protein function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. [The UniProt Consortium]