Anti-TRAIL-R1 (human), clone HS101, ATTO 647N conjugated

Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4. Liquid. In PBS containing 0.02% sodium azide. TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.