Anti-TPO (human), Rabbit Monoclonal (RM368)

Recombinant Antibody. This antibody reacts to human TPO (Thyroid peroxidase). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Thyroid Peroxidase (TPO) is a transmembrane protein of 107 kDa containing a heme prosthetic group and it is present on the apical surface of the thyroid follicular cells. It is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in thyroid peroxidase resulting in lower antibody affinity. TPO antibodies may be useful aid in the differentiation between the benign and malignant thyroid tumors. In diagnostic immunohistochemistry, the expression of thyroid peroxidase (TPO) is lost in papillary thyroid carcinoma.