Anti-TMEM106B

Anti-TMEM106B Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TMEM106B from other sources has not been determined. Protein function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. [The UniProt Consortium]