Anti-THAP11 (THAP Domain Containing 11, Ronin, CTG-B43a, CTG-B45d, HRIHFB2206)

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. THAP11, also known as Ronin, is a 3644kD member of the Thanatos-associated protein family. It is ubiquitously expressed and through its repression of cMyc transcription, blocks cell proliferation. Human THAP11 is 314aa in length. It contains a DNA binding THAP zinc-finger domain (aa5-81), an NLS (aa98-104 a polyGln region (aa104-146 an Ala-rich segment (aa 197-221 and a C-terminal coiled coil region (aa255-305 THAP11 is phosphorylated on Thr25. Over aa226-314 human and mouse THAP11 are 100% identical in aa sequence. Applications: Western Bloting: 1:500-1:2000., Immunohistochemistry: 1:200-1:1000., Immunofluorescence: 1:200-1:1000., Flow cytometry: 1:200-1:400., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.