Anti-TET2

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A304-247A-T 10 µl (10 µg) -

2 - 8 Werktage*

164,00 €
A304-247A 100 µl (100 µg) -

2 - 8 Werktage*

588,00 €
 
Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base... mehr
Produktinformationen "Anti-TET2"
Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. [The UniProt Consortium]
Schlagworte: Anti-TET2, Anti-KIAA1546, Anti-Nbla00191, Anti-Methylcytosine dioxygenase TET2
Hersteller: Bethyl Laboratories
Hersteller-Nr: A304-247A

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: chimpanzee, orangutan)
Immunogen: synthetic peptide. The epitope recognized by A304-247A-T maps to a region between residue 100 and 150 of human Tet Oncogene Family Member 2 using the numbering given in entry NP_001120680.1 (GeneID 54790).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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