Anti-TERF2IP

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TERF2IP antibody detects Telomeric repeat-binding factor 2-interacting protein, a critical component of the shelterin complex that protects chromosome ends and maintains telomere stability. Also known as RAP1, TERF2IP interacts with TERF2 to regulate telomeric structure, repress DNA damage signaling, and prevent end-to-end chromosome fusions. The TERF2IP antibody is widely used in studies of chromosome biology, DNA repair, and aging to investigate telomere function and genome protection mechanisms.TERF2IP is encoded by the TERF2IP gene located on human chromosome 16p13.3. The protein is approximately 399 amino acids long and consists of an N-terminal BRCT domain involved in protein interactions and a C-terminal Myb-like DNA-binding domain that anchors it to telomeric DNA via TERF2. TERF2IP localizes to telomeres throughout the cell cycle, forming a stabilizing subcomplex with TERF2 that suppresses activation of the ATM kinase pathway, a major mediator of DNA damage response.The TERF2IP antibody detects a 45-60 kilodalton band by western blot and shows punctate nuclear foci corresponding to telomere clusters by immunofluorescence. Beyond its telomeric role, TERF2IP functions in transcriptional regulation through the NF-kappaB pathway. In the cytoplasm, it interacts with the IKK complex and influences inflammatory signaling, demonstrating dual nuclear and cytoplasmic roles.Loss of TERF2IP function results in telomere uncapping, increased DNA damage foci, and cellular senescence. Mutations or mislocalization of TERF2IP have been linked to premature aging syndromes, cancer progression, and metabolic disorders. Its overexpression enhances survival of tumor cells under stress by repressing telomeric DNA damage checkpoints and promoting NF-kappaB-mediated gene expression.Because TERF2IP integrates telomere maintenance with stress and inflammatory signaling, it serves as an important marker for genomic stability and cancer biology research. NSJ Bioreagents provides a validated TERF2IP antibody optimized for western blot, immunofluorescence, and chromatin studies, supporting detailed examination of telomere integrity, transcriptional regulation, and DNA repair control.