Anti-SUMO-2, clone S2MT-1

Anti-SUMO-2, clone S2MT-1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V7051-20UG 20 µg - -

3 - 10 Werktage*

332,00 €
NSJ-V7051-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The small ubiquitin-related... mehr
Produktinformationen "Anti-SUMO-2, clone S2MT-1"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. Protein function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). [The UniProt Consortium]
Schlagworte: Anti-Smt3A, Anti-SUMO-2, Anti-SUMO-3, Anti-SMT3 homolog 1, Anti-Ubiquitin-like protein SMT3A, Anti-Small ubiquitin-related modifier 3, SUMO-2 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: V7051

Eigenschaften

Anwendung: IF, IHC (paraffin)
Antikörper-Typ: Monoclonal
Klon: S2MT-1
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, rat, species reactivity (Erwartet: broad)
Immunogen: Recombinant human protein was used as the immunogen for the SUMO-2 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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