Anti-STAM

Polyclonal Antibody against Human STAM, Gene description: signal transducing adaptor molecule, Alternative Gene Names: STAM1, Validated applications: ICC, WB, Uniprot ID: Q92783, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. [The UniProt Consortium] Mouse gene identity: 82% Rat gene identity: 82%