Protein function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. [The UniProt Consortium]
Anti-hSSB1, Anti-NABP2, Anti-OBFC2B, Anti-LP3587, Anti-SOSS-B1, Anti-SOSS complex subunit B1, Anti-Sensor of ssDNA subunit B1, Anti-Nucleic acid-binding protein 2, Anti-Single-stranded DNA-binding protein 1
synthetic peptide. The epitope recognized by A301-938A-T maps to a region between residue 161 and 211 of human single-stranded DNA-binding protein 1 using the numbering given in entry NP_076973.1 (GeneID 79035).