Anti-Sry

Sry Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Mouse and for use in ELISA applications. Sry Antibody is a high quality polyclonal antibody for research use only.. Protein function: Transcriptional regulator that controls a genetic switch in male development (PubMed:33004521). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:33004521). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:8190643, PubMed:8159753, PubMed:15170344). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed:8190643, PubMed:8159753, PubMed:15170344). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:8190643, PubMed:8159753, PubMed:15170344). Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. [The UniProt Consortium]