Anti-SNAP23 (Vesicle-membrane fusion protein SNAP-23)

SNAP23(Synaptosomal-Associated Protein, 23-KD), also called SNAP23A, is a protein that in humans , is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the initiation codon located in , exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino , acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59% identical to that of , SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to , bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After , relocation, SNAP23 is required for exocytosis, implying a crucial role in promoting membrane fusion. , TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A , and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl , maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and , functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is , an essential component of the high affinity receptor for the general membrane fusion machinery and is , an important regulator of transport vesicle docking and fusion. UniProt Number: O00161, Gene ID: SNAP23, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen). Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.