Anti-SHRM3

This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011], Protein function: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Cell junction, adherens junction . Cytoplasm, cytoskeleton . Apical cell membrane , Peripheral membrane protein . Colocalizes with F-actin in stress fibers and adherens junctions. .