Anti-SHPRH Magnetic Beads

Formulation: Supplied as solution in phosphate buffered saline containing 0.01% BSA and 0.02% sodium azide. Bead diameter: 0.5 µm. Antigen ID: ABS-PP-7709. Core Sequence: DKTKKQAVGS PRKIQKETRK SGNKDTDSEY LPSDTSDDDD DPYYYYYKSR RNRSKLRKKL VPSTKKGKSQ PFINPDSQGH CPATSDSGIT DVAMSKSTCI SEFNQEHETE DCAESLNHAD SDVPPSNTMS PFNTSDYRFE CICGELDQID RKPRVQCLKC HLWQHAKCVN. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 67%, Pig - 76%, Cynomolgus monkey - 93% Protein Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63' [The Uniprot Consortium]