Anti-SH3BP4

Anti-SH3BP4 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with SH3BP4 from other sources has not been determined. Protein function: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. [The UniProt Consortium]