Anti-S100, clone YN01456m

S-100 is a soluble acidic protein. There are three subtypes, namely s-100ao, s-100a and s-100b. S-100 mainly exists in nervous tissue, pituitary, carotid body, adrenal medulla, salivary glands, and few interlobular tissues, S-100 is mainly used to diagnose the astrocytoma oligodendroglioma, ependymoma, neuroblastoma, schwannoma, malignant melanoma and liposarcoma. Protein function: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). [The UniProt Consortium]